PDE11A

Across TCGA patient cohorts, PDE11A mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDE11A-associated genes across cancer lineages are ATM, MEK1, and P-Cadherin. Each is linked with PDE11A in more than 3 cancer types. Because this analysis shows association rather than direction, both PDE11A-to-partner and partner-to-PDE11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PDE11A-low versus PDE11A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE11A→partner) and Y-score (partner→PDE11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.669	-3.000	<.001	.035	3	4
UCEC	MEK1 →	+0.349	+2.000	.001	<.001	3	3
BLCA	P-Cadherin →	+0.240	+2.584	.017	.011	3	3
UCEC	4E-BP1 →	+0.240	+2.614	.002	<.001	3	3
LUSC	MYH11 →	-1.179	-3.000	.003	.033	3	2
COAD	p27_pT157 →	+0.135	+3.330	.048	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

ATM by PDE11A expression — COAD

Explore this box plot interactively →