PDE11A

Across TCGA pan-cancer cohorts, PDE11A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PDE11A data layer compared with 11 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PDE11A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDE11A expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

LUAD, BLCA, and SKCM are the cancer types where PDE11A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.596	0.761	<.001	115	view →
BLCA	DFS	Tertile	All	0.178	0.443	<.001	91	view →
SKCM	OS	Median	II,III,IV	0.781	0.898	.001	40	view →
THCA	DFS	Quartile	II,III,IV	0.363	0.801	.001	40	view →
KIRC	DFS	Tertile	II,III,IV	0.632	0.333	.007	34	view →
SCLC	DFS	Median	III,IV	0.968	0.338	.024	22	view →
CESC	DFS	Tertile	All	0.640	0.798	.006	16	view →
ESCA	DFS	Median	All	0.414	0.213	.001	16	view →
LAML	DFS	Quartile	All	0.334	0.677	.006	14	view →
TGCT	DFS	Quartile	All	0.710	0.951	.004	12	view →
PRAD	DFS	Tertile	All	0.882	0.667	.011	12	view →
READ	OS	Median	II,III,IV	1.000	0.848	.009	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PDE11A–LUAD (DFS)

Open the LUAD breakdown →