PDE11A

Across TCGA cell cohorts, PDE11A RNA expression is significantly associated with the go_rna of many other GO terms, with 1,650 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PDE11A-associated GO terms across cancer lineages are Cytosolic transport, Establishment of protein localization to organelle, and Regulation of protein lipidation. Each is linked with PDE11A in more than 10 cancer types. Because this analysis shows association rather than direction, both PDE11A-to-partner and partner-to-PDE11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytosolic transport grouped by PDE11A-low versus PDE11A-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE11A→partner) and Y-score (partner→PDE11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cytosolic transport →	+0.035	+1.246	.002	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Establishment of protein localization to organelle →	+0.065	+0.164	<.001	.004	3	9
LUNG_NSCLC_LUSC	Regulation of protein lipidation →	+0.153	+0.386	<.001	.001	3	8
BREAST	Post-Golgi vesicle-mediated transport →	+0.070	+0.323	.005	.002	1	9
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.063	+0.127	<.001	.008	2	8
KIDNEY	Regulation of stress-activated MAPK cascade →	+0.131	+2.092	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,650 associations by consensus.

Cytosolic transport by PDE11A expression — LUNG_SCLC

Explore this box plot interactively →