PDE11A

Across TCGA cell cohorts, PDE11A mutation is significantly associated with the RNA expression of many other genes, with 264 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE11A-associated genes across cancer lineages are ASCL4, KRTAP12-3, and OR2M4. Each is linked with PDE11A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE11A-to-partner and partner-to-PDE11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASCL4 grouped by PDE11A-low versus PDE11A-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE11A→partner) and Y-score (partner→PDE11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ASCL4 →	+0.006	+5.614	<.001	.002	3	2
BLOOD_Leukemia	KRTAP12-3 →	+0.087	+4.539	<.001	.007	3	2
OVARY	OR2M4 →	+0.076	+4.700	<.001	.002	3	2
LUNG_NSCLC_LUAD	ANKRD34C →	+0.065	+4.212	<.001	.007	3	2
SOFT_TISSUE	H2BC1 →	+0.325	+4.977	<.001	.002	3	1
SOFT_TISSUE	H2AC1 →	+0.145	+4.977	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 264 associations by consensus.

ASCL4 by PDE11A expression — PANCREAS

Explore this box plot interactively →