PDCL3P4

Across TCGA patient cohorts, PDCL3P4 mutation is significantly associated with the RNA expression of many other genes, with 281 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCL3P4-associated genes across cancer lineages are RNU6-874P, RNU4-58P, and RNU4-61P. Each is linked with PDCL3P4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCL3P4-to-partner and partner-to-PDCL3P4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-874P grouped by PDCL3P4-low versus PDCL3P4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCL3P4→partner) and Y-score (partner→PDCL3P4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-874P →	+0.460	+5.771	<.001	.003	3	2
UCEC	RNU4-58P →	+0.500	+4.396	<.001	<.001	3	2
UCEC	RNU4-61P →	+0.482	+2.813	<.001	.003	3	2
UCEC	IGLV3-31 →	+0.538	+2.823	<.001	.001	3	2
SKCM	RN7SL332P →	+0.223	+6.199	<.001	.001	3	2
BLCA	RN7SKP154 →	+0.109	+4.704	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 281 associations by consensus.

RNU6-874P by PDCL3P4 expression — SKCM

Explore this box plot interactively →