PCSK4

Across TCGA patient cohorts, PCSK4 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,157 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PCSK4-associated proteins across cancer lineages are MYO5A, REEP6, and HSP90B1. Each is linked with PCSK4 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCSK4-to-partner and partner-to-PCSK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCSK4 versus MYO5A in GBM, with a Pearson correlation of -0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK4→partner) and Y-score (partner→PCSK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYO5A →	-0.415	-0.487	.001	<.001	3	4
BRCA	REEP6 →	+0.850	+0.859	<.001	<.001	3	4
BRCA	HSP90B1 →	-0.263	-0.759	.001	.001	3	4
HNSC	GAMT →	+0.631	+0.748	<.001	.002	2	5
BRCA	STUB1 →	+0.476	+1.113	<.001	<.001	3	4
GBM	PPL →	+0.762	+0.546	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,157 associations by consensus.

PCSK4 vs MYO5A — GBM

Explore this scatter interactively →