PCSK2

Across TCGA patient cohorts, PCSK2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,013 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PCSK2-associated genes across cancer lineages are EPHA3, SOX10, and SEPTIN3. Each is linked with PCSK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCSK2-to-partner and partner-to-PCSK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCSK2 versus EPHA3 in LSCC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK2→partner) and Y-score (partner→PCSK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EPHA3 →	+1.331	+0.396	.001	.003	3	2
GBM	SOX10 →	+1.430	+0.469	<.001	<.001	3	2
GBM	SEPTIN3 →	+1.430	+0.604	<.001	<.001	3	2
GBM	NEFH →	+1.038	+0.488	<.001	<.001	3	2
GBM	SYNGR1 →	+0.754	+0.500	<.001	<.001	3	2
GBM	CACNA1I →	+0.532	+0.558	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,013 associations by consensus.

PCSK2 vs EPHA3 — LSCC

Explore this scatter interactively →