PCSK2

Across TCGA pan-cancer cohorts, PCSK2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PCSK2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PCSK2 RNA is repressed in tumor relative to normal tissue. In most cancer types PCSK2 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and KIRP are the cancer types where PCSK2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCSK2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−1.707	<.001	12	view →
BLCA	Male	IV	−2.072	<.001	11	view →
KIRP	Male	All	−0.329	<.001	9	view →
KIRC	Male	All	−0.212	<.001	8	view →
STAD	All	All	−1.294	<.001	7	view →
THCA	Female	II,III,IV	+3.604	<.001	6	view →
LUSC	Male	All	−1.911	<.001	6	view →
UCEC	All	All	−1.116	<.001	6	view →
HNSC	Female	All	−0.551	.022	4	view →
KICH	Male	II,III,IV	−0.210	<.001	4	view →
READ	Female	All	−2.316	<.001	3	view →
LUAD	All	All	−0.745	.019	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PCSK2–COAD

Open the COAD breakdown →