PCSK2

Across TCGA pan-cancer cohorts, PCSK2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PCSK2 data layer compared with 12 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PCSK2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PCSK2 expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

SKCM, KIRC, and LGG are the cancer types where PCSK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.620	0.782	.002	53	view →
KIRC	DFS	Tertile	III,IV	0.354	0.556	.004	46	view →
LGG	DFS	Median	All	0.881	0.782	<.001	30	view →
UVM	DFS	Median	All	0.401	0.714	.005	25	view →
PAAD	DFS	Median	All	0.372	0.180	.001	23	view →
LIHC	DFS	Tertile	II,III,IV	0.216	0.363	.015	22	view →
HNSC	OS	Tertile	III,IV	0.145	0.421	.003	21	view →
LUAD	OS	Quartile	II,III,IV	0.780	0.544	.018	18	view →
LAML	DFS	Tertile	All	0.646	0.434	.014	18	view →
PCPG	DFS	Tertile	All	1.000	0.699	.013	17	view →
CHOL	DFS	Median	All	0.609	0.238	.028	12	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.038	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PCSK2–SKCM (OS)

Open the SKCM breakdown →