PCSK2

Across TCGA cell cohorts, PCSK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,765 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PCSK2-associated GO terms across cancer lineages are Regulation of nucleotide-excision repair, Positive regulation of cytoplasmic mRNA processing body assembly, and Regulation of smooth muscle cell-matrix adhesion. Each is linked with PCSK2 in more than 5 cancer types. Because this analysis shows association rather than direction, both PCSK2-to-partner and partner-to-PCSK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-excision repair grouped by PCSK2-low versus PCSK2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK2→partner) and Y-score (partner→PCSK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of nucleotide-excision repair →	+0.139	+3.773	<.001	<.001	3	6
LUNG_SCLC	Positive regulation of cytoplasmic mRNA processing body assembly →	+0.109	+3.117	.003	<.001	3	5
BONE	Regulation of smooth muscle cell-matrix adhesion →	-0.747	-4.194	.003	<.001	3	5
BONE	Regulation of CD4-positive, alpha-beta T cell proliferation →	-0.179	-3.427	<.001	<.001	3	5
LUNG_SCLC	Collagen catabolic process →	-0.244	-4.316	<.001	<.001	3	5
BONE	Negative regulation of cellular response to growth factor stimulus →	-0.088	-3.942	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,765 associations by consensus.

Regulation of nucleotide-excision repair by PCSK2 expression — BONE

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