PCSK2

Across TCGA cell cohorts, PCSK2 mutation is significantly associated with the RNA expression of many other genes, with 109 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PCSK2-associated genes across cancer lineages are PRM3, OR14A2, and PHOX2B. Each is linked with PCSK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCSK2-to-partner and partner-to-PCSK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRM3 grouped by PCSK2-low versus PCSK2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK2→partner) and Y-score (partner→PCSK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRM3 →	+0.178	+5.754	<.001	.002	3	1
BREAST	OR14A2 →	+0.035	+5.169	<.001	.005	3	1
BLOOD_Leukemia	PHOX2B →	+0.015	+3.365	<.001	<.001	3	1
BLOOD_Leukemia	TECTA →	+0.213	+3.470	.009	.002	3	1
BLOOD_Leukemia	PTPN5 →	+0.292	+3.197	.002	.002	3	1
BLOOD_Leukemia	PZP →	+0.054	+2.517	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 109 associations by consensus.

PRM3 by PCSK2 expression — CNS

Explore this box plot interactively →