PCSK1

Across TCGA cell cohorts, PCSK1 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PCSK1-associated genes across cancer lineages are OR4X2, SPAM1, and MROH5. Each is linked with PCSK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCSK1-to-partner and partner-to-PCSK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by PCSK1-low versus PCSK1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK1→partner) and Y-score (partner→PCSK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4X2 →	+0.018	+5.369	.001	.004	3	2
OESOPHAGUS	SPAM1 →	+0.013	+4.906	<.001	.006	3	1
SOFT_TISSUE	MROH5 →	+0.021	+4.930	<.001	.008	3	1
SOFT_TISSUE	LCE6A →	+0.040	+5.977	<.001	.001	3	1
URINARY_TRACT	DRD3 →	+0.023	+5.087	<.001	.004	3	1
URINARY_TRACT	CCL11 →	+0.023	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR4X2 by PCSK1 expression — SOFT_TISSUE

Explore this box plot interactively →