PCSK1

Across TCGA pan-cancer cohorts, PCSK1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PCSK1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PCSK1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PCSK1 is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

HNSC, LUSC, and KIRP are the cancer types where PCSK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCSK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.285	<.001	11	view →
LUSC	Female	All	+0.841	<.001	8	view →
KIRP	Male	All	−0.188	<.001	8	view →
LUAD	Male	All	+1.276	<.001	5	view →
BRCA	Female	All	+0.639	<.001	4	view →
THCA	All	All	−0.334	<.001	4	view →
ESCA	Female	All	−1.060	.025	1	view →
KICH	Female	II,III,IV	−0.267	.034	1	view →
STAD	Male	IV	−0.234	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PCSK1–HNSC

Open the HNSC breakdown →