PCOLCE

Across TCGA patient cohorts, PCOLCE mutation is significantly associated with the RNA expression of many other genes, with 1,197 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCOLCE-associated genes across cancer lineages are TRAJ43, MIR6803, and AOC2. Each is linked with PCOLCE in more than 2 cancer types. Because this analysis shows association rather than direction, both PCOLCE-to-partner and partner-to-PCOLCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ43 grouped by PCOLCE-low versus PCOLCE-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCOLCE→partner) and Y-score (partner→PCOLCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRAJ43 →	+0.733	+3.708	.001	.003	3	3
UCEC	MIR6803 →	+0.119	+4.086	<.001	.005	3	3
UCEC	AOC2 →	+1.081	+2.423	<.001	.001	3	2
UCEC	IL21 →	+0.092	+1.901	.008	.001	3	2
UCEC	CBX4 →	+0.366	+1.931	.009	.009	3	2
UCEC	TRAJ9 →	+0.607	+1.917	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,197 associations by consensus.

TRAJ43 by PCOLCE expression — LUAD

Explore this box plot interactively →