PCOLCE

Across TCGA pan-cancer cohorts, PCOLCE RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PCOLCE’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PCOLCE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PCOLCE is over-expressed in tumor, although a few such as BLCA show the opposite, repressed pattern.

HNSC, BLCA, and LUAD are the cancer types where PCOLCE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCOLCE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.396	<.001	11	view →
BLCA	Male	III,IV	−1.121	.016	5	view →
LUAD	All	III,IV	+0.797	.014	5	view →
COAD	Female	All	+0.620	.015	3	view →
STAD	Male	II,III,IV	+1.355	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PCOLCE–HNSC

Open the HNSC breakdown →