PCOLCE

Across TCGA pan-cancer cohorts, PCOLCE RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PCOLCE data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PCOLCE RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PCOLCE expression acts as an unfavorable survival marker, although some lineages such as DLBC and LUAD show a favorable association.

KIRC, UVM, and KICH are the cancer types where PCOLCE RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Quartile	II,III,IV	0.418	0.659	.002	93	view →
UVM	DFS	Tertile	All	0.615	0.928	.001	90	view →
KICH	OS	Median	III,IV	0.733	1.000	.001	67	view →
LGG	OS	Median	All	0.336	0.562	<.001	54	view →
ACC	DFS	Tertile	II,III,IV	0.163	0.679	<.001	52	view →
DLBC	DFS	Tertile	All	1.000	0.246	.001	35	view →
LUAD	DFS	Quartile	III,IV	0.675	0.194	.002	19	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	17	view →
HNSC	OS	Median	All	0.622	0.797	.001	17	view →
STAD	DFS	Tertile	IV	0.142	0.670	.014	14	view →
TGCT	DFS	Quartile	All	0.558	0.794	.008	12	view →
LUSC	DFS	Median	II,III,IV	0.540	0.678	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PCOLCE–KIRC (OS)

Open the KIRC breakdown →