PCOLCE

Across TCGA cell cohorts, PCOLCE RNA expression is significantly associated with the go_rna of many other GO terms, with 4,486 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PCOLCE-associated GO terms across cancer lineages are Collagen biosynthetic process, Cell division, and Negative regulation of smoothened signaling pathway. Each is linked with PCOLCE in more than 14 cancer types. Because this analysis shows association rather than direction, both PCOLCE-to-partner and partner-to-PCOLCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Collagen biosynthetic process grouped by PCOLCE-low versus PCOLCE-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCOLCE→partner) and Y-score (partner→PCOLCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Collagen biosynthetic process →	+0.305	+2.915	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Cell division →	+0.075	+1.673	.004	.005	3	11
LARGE_INTESTINE	Negative regulation of smoothened signaling pathway →	+0.065	+1.122	<.001	<.001	3	10
LARGE_INTESTINE	Nucleoside triphosphate metabolic process →	+0.068	+1.356	<.001	<.001	3	10
BONE	Collagen metabolic process →	+0.283	+3.061	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.096	+1.452	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,486 associations by consensus.

Collagen biosynthetic process by PCOLCE expression — BONE

Explore this box plot interactively →