PCOLCE

Across TCGA cell cohorts, PCOLCE mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCOLCE-associated genes across cancer lineages are TTLL8, COX6A2, and TBC1D21. Each is linked with PCOLCE in more than 1 cancer types. Because this analysis shows association rather than direction, both PCOLCE-to-partner and partner-to-PCOLCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by PCOLCE-low versus PCOLCE-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCOLCE→partner) and Y-score (partner→PCOLCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	WDR87 →	+0.017	+3.453	.003	.009	3	1
LARGE_INTESTINE	OR52H1 →	+0.032	+3.347	<.001	.005	3	1
LARGE_INTESTINE	TRDN →	+0.030	+4.376	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TTLL8 by PCOLCE expression — LARGE_INTESTINE

Explore this box plot interactively →