PEST containing nuclear protein pseudogene 5Genealiases: []
Q-omics provides the consensus-scored PCNPP5 profile across patient tissues and cancer cell-line models. PCNPP5 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, PCNPP5 is differentially expressed in 5, with the highest sampling consensus in KICH. Additionally, PCNPP5 RNA expression shows 14,256 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight HNSC, KICH, and THYM as cancer lineages where PCNPP5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PCNPP5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PCNPP5 survival associations across molecular data types. PCNPP5 RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PCNPP5 RNA expression–survival associations across cancer types. High PCNPP5 expression shows unfavorable associations in LGG, THYM and OV, but favorable associations in HNSC, SKCM and BRCA. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .002). Together, the overview and detailed table identify HNSC as the clearest survival context for PCNPP5 RNA expression.
This table summarizes PCNPP5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in KICH for RNA.
This table ranks reproducible tumor–normal expression differences for PCNPP5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PCNPP5 shows lower tumor expression in KICH, UCEC and LIHC and higher tumor expression in COAD and KIRC. The KICH box plot shows higher PCNPP5 RNA expression in normal versus tumor tissue (log2 FC = −0.342, t-test p < 0.001).
This table shows molecular features associated with PCNPP5 in patient tissues and cancer cell lines. In patient samples, PCNPP5 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
