PCNPP5

Across TCGA pan-cancer cohorts, PCNPP5 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated PCNPP5 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PCNPP5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PCNPP5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LGG are the cancer types where PCNPP5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.650	0.452	.002	46	view →
SKCM	OS	Tertile	III,IV	0.543	0.279	<.001	36	view →
LGG	OS	Tertile	All	0.381	0.555	<.001	34	view →
THYM	DFS	Median	All	0.539	1.000	<.001	30	view →
OV	OS	Median	III,IV	0.636	0.720	.002	24	view →
BRCA	DFS	Tertile	III,IV	0.935	0.812	.008	23	view →
LUAD	DFS	Tertile	IV	0.747	0.139	.011	18	view →
UCS	DFS	Tertile	IV	0.857	0.361	.024	12	view →
CHOL	OS	Tertile	All	0.914	0.470	.006	12	view →
KIRC	DFS	Quartile	II,III,IV	0.715	0.887	.003	12	view →
THCA	DFS	Tertile	IV	1.000	0.603	.022	11	view →
ACC	OS	Quartile	IV	0.666	0.244	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

PCNPP5–HNSC (DFS)

Open the HNSC breakdown →