PCNA

Across TCGA patient cohorts, PCNA mutation is significantly associated with the RNA expression of many other genes, with 446 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCNA-associated genes across cancer lineages are SAPCD2P2, RN7SL468P, and RNA5SP213. Each is linked with PCNA in more than 1 cancer types. Because this analysis shows association rather than direction, both PCNA-to-partner and partner-to-PCNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAPCD2P2 grouped by PCNA-low versus PCNA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCNA→partner) and Y-score (partner→PCNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SAPCD2P2 →	+0.036	+5.159	<.001	.007	3	2
UCEC	RN7SL468P →	+0.096	+3.008	<.001	.007	3	2
UCEC	RNA5SP213 →	+0.522	+3.008	<.001	.007	3	2
LUSC	RNU6-441P →	+0.533	+5.211	<.001	.007	3	1
LUSC	RN7SL645P →	+0.168	+5.038	<.001	.009	3	1
LUSC	NBEAP5 →	+0.374	+5.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 446 associations by consensus.

SAPCD2P2 by PCNA expression — SKCM

Explore this box plot interactively →