PCNA

Across TCGA pan-cancer cohorts, PCNA RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated PCNA data layer compared with 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher PCNA RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PCNA expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

MESO, ACC, and UVM are the cancer types where PCNA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.374	0.701	<.001	162	view →
ACC	OS	Median	All	0.659	0.921	<.001	86	view →
UVM	DFS	Quartile	All	0.276	0.772	<.001	84	view →
LIHC	DFS	Median	All	0.457	0.626	<.001	60	view →
KIRP	DFS	Tertile	All	0.844	0.963	<.001	58	view →
LGG	OS	Median	All	0.710	0.906	<.001	54	view →
PAAD	DFS	Quartile	All	0.355	0.586	.001	46	view →
KICH	DFS	Quartile	III,IV	0.086	1.000	.007	42	view →
KIRC	DFS	Tertile	II,III,IV	0.741	0.433	.001	36	view →
SCLC	DFS	Tertile	All	0.518	1.000	.003	29	view →
SARC	OS	Quartile	All	0.435	0.814	.004	22	view →
READ	OS	Quartile	All	0.930	0.436	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

PCNA–MESO (OS)

Open the MESO breakdown →