PCMT1

Across TCGA patient cohorts, PCMT1 mutation is significantly associated with the RNA expression of many other genes, with 1,115 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCMT1-associated genes across cancer lineages are RN7SL248P, RNU6-864P, and RNU6-718P. Each is linked with PCMT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCMT1-to-partner and partner-to-PCMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by PCMT1-low versus PCMT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCMT1→partner) and Y-score (partner→PCMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.059	+3.137	<.001	.005	3	3
LUAD	RNU6-864P →	+0.468	+7.930	<.001	.008	3	2
UCEC	RNU6-718P →	+0.122	+3.292	.001	.003	3	2
COAD	VWC2L-IT1 →	+0.218	+6.721	<.001	<.001	3	2
COAD	LDHBP3 →	+0.255	+6.392	<.001	.001	3	2
LUAD	OR5I1 →	+0.034	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,115 associations by consensus.

RN7SL248P by PCMT1 expression — UCEC

Explore this box plot interactively →