PCF11

Across TCGA cell cohorts, PCF11 mutation is significantly associated with the RNA expression of many other genes, with 320 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCF11-associated genes across cancer lineages are CT45A7, GAGE12J, and GNGT1. Each is linked with PCF11 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCF11-to-partner and partner-to-PCF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT45A7 grouped by PCF11-low versus PCF11-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCF11→partner) and Y-score (partner→PCF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CT45A7 →	+0.031	+3.362	<.001	.007	3	2
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
BLOOD_Leukemia	GNGT1 →	+0.050	+4.551	.002	.004	3	1
BLOOD_Leukemia	ANGPTL5 →	+0.022	+4.276	.007	.007	3	1
BLOOD_Leukemia	TEX43 →	+0.105	+4.969	<.001	.003	3	1
BLOOD_Leukemia	CCT8L2 →	+0.019	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 320 associations by consensus.

CT45A7 by PCF11 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →