PCF11

Across TCGA pan-cancer cohorts, PCF11 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated PCF11 data layer compared with 9 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PCF11 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PCF11 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

HNSC, ACC, and SCLC are the cancer types where PCF11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.763	0.579	<.001	96	view →
ACC	DFS	Median	All	0.242	0.661	<.001	82	view →
SCLC	DFS	Median	II,III,IV	0.618	0.299	.002	50	view →
BLCA	OS	Quartile	All	0.596	0.362	.001	43	view →
UCS	DFS	Median	IV	0.952	0.367	.001	42	view →
BRCA	OS	Median	III,IV	0.948	0.855	.005	30	view →
GBM	OS	Median	All	0.556	0.260	<.001	27	view →
CESC	DFS	Tertile	III,IV	0.242	0.894	.004	26	view →
UVM	DFS	Quartile	III,IV	0.182	0.814	.003	26	view →
KIRC	DFS	Quartile	All	0.884	0.694	.002	18	view →
READ	OS	Quartile	II,III,IV	1.000	0.253	.006	18	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.485	.006	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

PCF11–HNSC (OS)

Open the HNSC breakdown →