PCDHGB6

Across TCGA patient cohorts, PCDHGB6 mutation is significantly associated with the RNA expression of many other genes, with 5,325 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHGB6-associated genes across cancer lineages are UBE2S, AZGP1, and CATSPER3. Each is linked with PCDHGB6 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHGB6-to-partner and partner-to-PCDHGB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2S grouped by PCDHGB6-low versus PCDHGB6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGB6→partner) and Y-score (partner→PCDHGB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	UBE2S →	+0.603	+3.611	<.001	.001	3	4
COAD	AZGP1 →	-1.182	-3.584	<.001	.002	3	4
COAD	CATSPER3 →	+0.335	+3.625	<.001	.001	3	3
COAD	ENO2 →	+0.844	+3.584	.001	.002	3	3
COAD	GUCA1B →	+0.518	+3.210	<.001	.009	3	3
COAD	UBE2M →	+0.350	+3.000	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,325 associations by consensus.

UBE2S by PCDHGB6 expression — COAD

Explore this box plot interactively →