PCDHGB6

Across TCGA pan-cancer cohorts, PCDHGB6 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PCDHGB6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PCDHGB6 RNA is repressed in tumor relative to normal tissue. In most cancer types PCDHGB6 is over-expressed in tumor, although a few such as HNSC and LUSC show the opposite, repressed pattern.

HNSC, LUSC, and KICH are the cancer types where PCDHGB6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCDHGB6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−0.556	<.001	8	view →
LUSC	Female	All	−0.975	<.001	7	view →
KICH	Male	II,III,IV	−0.790	<.001	7	view →
UCEC	All	All	−1.304	<.001	6	view →
BRCA	All	All	−0.699	<.001	6	view →
KIRP	All	II,III,IV	−0.525	<.001	6	view →
THCA	All	II,III,IV	−0.513	.001	6	view →
BLCA	Male	IV	−0.550	.023	5	view →
LUAD	Female	All	−0.441	<.001	5	view →
KIRC	Female	IV	−0.423	.025	2	view →
COAD	All	III,IV	−0.389	.024	2	view →
CHOL	All	All	+1.075	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PCDHGB6–HNSC

Open the HNSC breakdown →