PCDHGB6

Across TCGA cell cohorts, PCDHGB6 mutation is significantly associated with the RNA expression of many other genes, with 1,251 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGB6-associated genes across cancer lineages are TAS2R39, CCNI, and FAM153B. Each is linked with PCDHGB6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGB6-to-partner and partner-to-PCDHGB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R39 grouped by PCDHGB6-low versus PCDHGB6-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGB6→partner) and Y-score (partner→PCDHGB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TAS2R39 →	+0.043	+4.906	<.001	.006	3	2
LARGE_INTESTINE	CCNI →	+0.513	+3.588	.007	<.001	3	2
LARGE_INTESTINE	FAM153B →	+0.342	+2.448	.002	.003	3	2
CNS	AVP →	+0.048	+4.981	.001	.008	3	2
PANCREAS	PRM2 →	+0.128	+5.000	<.001	.006	3	1
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,251 associations by consensus.

TAS2R39 by PCDHGB6 expression — OESOPHAGUS

Explore this box plot interactively →