PCDHGB1

Across TCGA cell cohorts, PCDHGB1 mutation is significantly associated with the RNA expression of many other genes, with 221 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHGB1-associated genes across cancer lineages are SERP1, TMEM50B, and CRYGD. Each is linked with PCDHGB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHGB1-to-partner and partner-to-PCDHGB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERP1 grouped by PCDHGB1-low versus PCDHGB1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHGB1→partner) and Y-score (partner→PCDHGB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SERP1 →	+0.561	+3.206	.007	.006	3	2
LUNG_NSCLC_LUAD	TMEM50B →	+0.767	+3.206	<.001	.006	3	2
LUNG_SCLC	CRYGD →	+0.571	+3.232	.001	.001	3	1
LUNG_SCLC	FBP2 →	+0.134	+3.392	<.001	.003	3	1
LUNG_SCLC	RBM46 →	+1.002	+2.781	<.001	.009	3	1
LUNG_SCLC	OR14K1 →	+0.066	+2.684	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 221 associations by consensus.

SERP1 by PCDHGB1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →