PCDHB6

Across TCGA cell cohorts, PCDHB6 mutation is significantly associated with the RNA expression of many other genes, with 994 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHB6-associated genes across cancer lineages are C9orf92, DYDC2, and MAPK8. Each is linked with PCDHB6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDHB6-to-partner and partner-to-PCDHB6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by PCDHB6-low versus PCDHB6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB6→partner) and Y-score (partner→PCDHB6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C9orf92 →	+0.071	+2.669	<.001	.004	3	2
LUNG_NSCLC_LUAD	DYDC2 →	+0.291	+3.330	.006	.008	3	2
LARGE_INTESTINE	MAPK8 →	+0.664	+3.169	.002	.009	3	2
BLOOD_Leukemia	CNOT6 →	+0.587	+2.730	<.001	.001	3	2
LARGE_INTESTINE	PAPOLG →	+0.389	+3.237	.002	.003	3	2
LARGE_INTESTINE	WRAP73 →	+0.521	+2.628	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 994 associations by consensus.

C9orf92 by PCDHB6 expression — SKIN

Explore this box plot interactively →