PCDHB6

Across TCGA pan-cancer cohorts, PCDHB6 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PCDHB6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PCDHB6 RNA is repressed in tumor relative to normal tissue. In most cancer types PCDHB6 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, KIRC, and BRCA are the cancer types where PCDHB6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCDHB6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.098	<.001	11	view →
KIRC	Male	All	+0.920	<.001	9	view →
BRCA	Female	All	−0.791	<.001	6	view →
KIRP	Male	III,IV	+1.164	.007	4	view →
LIHC	All	All	+0.244	<.001	4	view →
LUSC	Male	All	+0.858	.003	3	view →
UCEC	All	All	−0.966	<.001	2	view →
CHOL	Male	All	+0.720	.010	2	view →
READ	Female	All	−0.672	.007	2	view →
THCA	Male	II,III,IV	−0.337	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PCDHB6–KICH

Open the KICH breakdown →