PCDHB16

Across TCGA patient cohorts, PCDHB16 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHB16-associated genes across cancer lineages are GAPDH, ERK2, and ACC_pS79. Each is linked with PCDHB16 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHB16-to-partner and partner-to-PCDHB16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PCDHB16-low versus PCDHB16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB16→partner) and Y-score (partner→PCDHB16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.286	+1.925	.042	.004	3	4
UCEC	ERK2 →	+0.130	+1.662	.009	.009	3	3
UCEC	ACC_pS79 →	+0.206	+1.074	.023	.029	3	3
LUAD	p90 RSK_pT359_S363 →	-0.149	-2.700	.028	.006	3	2
COAD	PDK1 →	-0.118	-3.584	.005	.002	3	2
COAD	Src →	-0.208	-1.691	.005	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

GAPDH by PCDHB16 expression — UCEC

Explore this box plot interactively →