PCDHB16

Across TCGA pan-cancer cohorts, PCDHB16 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PCDHB16 data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher PCDHB16 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCDHB16 expression acts as an unfavorable survival marker, although some lineages such as KIRP and UVM show a favorable association.

BRCA, BLCA, and KIRP are the cancer types where PCDHB16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Quartile	II,III,IV	0.875	0.942	.002	83	view →
BLCA	DFS	Median	All	0.256	0.417	<.001	82	view →
KIRP	OS	Quartile	III,IV	0.841	0.410	.001	69	view →
UVM	OS	Median	II,III,IV	0.836	0.594	.005	66	view →
LGG	OS	Median	All	0.735	0.886	<.001	50	view →
THCA	OS	Tertile	III,IV	0.921	1.000	.002	27	view →
STAD	DFS	Median	All	0.489	0.612	.004	26	view →
SARC	DFS	Quartile	All	0.261	0.637	<.001	26	view →
LUSC	DFS	Quartile	III,IV	0.227	0.562	.014	21	view →
HNSC	OS	Quartile	All	0.603	0.822	.001	21	view →
SKCM	OS	Tertile	II,III,IV	0.566	0.361	.012	18	view →
MESO	OS	Tertile	IV	0.238	0.666	.026	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PCDHB16–BRCA (DFS)

Open the BRCA breakdown →