PCDHB16

Across TCGA cell cohorts, PCDHB16 mutation is significantly associated with the RNA expression of many other genes, with 246 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHB16-associated genes across cancer lineages are GALNTL5, PTH2, and GSTT4. Each is linked with PCDHB16 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHB16-to-partner and partner-to-PCDHB16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALNTL5 grouped by PCDHB16-low versus PCDHB16-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHB16→partner) and Y-score (partner→PCDHB16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GALNTL5 →	+0.033	+2.637	<.001	.007	3	2
LUNG_NSCLC_LUAD	PTH2 →	+0.094	+2.803	.002	.003	3	2
BLOOD_Leukemia	GSTT4 →	+0.103	+2.681	<.001	.008	3	2
LARGE_INTESTINE	REEP4 →	+0.680	+3.212	.004	.006	3	2
LARGE_INTESTINE	TECRL →	+0.008	+2.754	.002	.009	3	2
SKIN	APOL5 →	+0.067	+3.760	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 246 associations by consensus.

GALNTL5 by PCDHB16 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →