PCDHA13

Across TCGA cell cohorts, PCDHA13 mutation is significantly associated with the RNA expression of many other genes, with 1,226 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDHA13-associated genes across cancer lineages are CLRN1, OR6B2, and OR10G4. Each is linked with PCDHA13 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDHA13-to-partner and partner-to-PCDHA13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLRN1 grouped by PCDHA13-low versus PCDHA13-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA13→partner) and Y-score (partner→PCDHA13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CLRN1 →	+0.033	+5.087	<.001	.004	3	2
OVARY	OR6B2 →	+0.034	+3.624	.003	.005	3	2
OVARY	OR10G4 →	+0.017	+3.754	<.001	.002	3	2
LARGE_INTESTINE	CCDC134 →	+0.588	+1.628	.002	.002	3	2
LARGE_INTESTINE	L3MBTL2 →	+0.556	+1.969	<.001	<.001	3	2
LARGE_INTESTINE	ACO2 →	+0.441	+2.064	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,226 associations by consensus.

CLRN1 by PCDHA13 expression — URINARY_TRACT

Explore this box plot interactively →