PCDHA13

Across TCGA pan-cancer cohorts, PCDHA13 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PCDHA13’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PCDHA13 RNA is repressed in tumor relative to normal tissue. In most cancer types PCDHA13 is over-expressed in tumor, although a few such as HNSC and UCEC show the opposite, repressed pattern.

HNSC, UCEC, and KICH are the cancer types where PCDHA13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCDHA13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.045	.011	5	view →
UCEC	All	All	−0.186	<.001	4	view →
KICH	All	All	−0.134	.003	3	view →
PRAD	All	All	+0.321	.005	2	view →
LUAD	Male	All	+0.293	.021	2	view →
KIRC	All	IV	−0.140	.011	2	view →
LUSC	Female	II,III,IV	−0.201	.001	1	view →
BRCA	Female	All	+0.103	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PCDHA13–HNSC

Open the HNSC breakdown →