PCDHA10

Across TCGA patient cohorts, PCDHA10 mutation is significantly associated with the RNA expression of many other genes, with 5,338 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA10-associated genes across cancer lineages are ECHS1, CXXC1, and TXN2. Each is linked with PCDHA10 in more than 5 cancer types. Because this analysis shows association rather than direction, both PCDHA10-to-partner and partner-to-PCDHA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECHS1 grouped by PCDHA10-low versus PCDHA10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA10→partner) and Y-score (partner→PCDHA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ECHS1 →	+0.205	+1.533	.008	.004	3	6
COAD	CXXC1 →	+0.383	+1.946	<.001	<.001	3	5
BLCA	TXN2 →	+0.409	+3.354	.002	.005	3	4
COAD	PALD1 →	-0.499	-2.794	.008	.002	3	4
COAD	MLPH →	+0.816	+1.673	.001	.006	3	4
UCEC	SDHB →	+0.264	+1.338	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,338 associations by consensus.

ECHS1 by PCDHA10 expression — SKCM

Explore this box plot interactively →