PCDHA10

Across TCGA pan-cancer cohorts, PCDHA10 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PCDHA10’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PCDHA10 RNA is repressed in tumor relative to normal tissue. In most cancer types PCDHA10 is over-expressed in tumor, although a few such as KIRC and LUSC show the opposite, repressed pattern.

KIRC, LUSC, and KICH are the cancer types where PCDHA10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCDHA10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−0.771	<.001	9	view →
LUSC	Female	All	−0.454	<.001	4	view →
KICH	Male	III,IV	−0.612	.020	3	view →
KIRP	Female	II,III,IV	−0.770	.016	2	view →
UCEC	All	All	−0.526	<.001	2	view →
CHOL	All	All	+0.365	.032	2	view →
PRAD	All	All	+0.250	.039	2	view →
READ	Female	All	−0.162	.001	2	view →
THCA	All	All	−0.258	.047	1	view →
STAD	Female	III,IV	−0.200	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PCDHA10–KIRC

Open the KIRC breakdown →