PCDHA10

Across TCGA patient cohorts, PCDHA10 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDHA10-associated genes across cancer lineages are ER-alpha_pS118, 4E-BP1, and MYH11. Each is linked with PCDHA10 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCDHA10-to-partner and partner-to-PCDHA10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by PCDHA10-low versus PCDHA10-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDHA10→partner) and Y-score (partner→PCDHA10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ER-alpha_pS118 →	+0.169	+2.321	.022	.035	3	4
UCEC	4E-BP1 →	+0.326	+2.584	<.001	<.001	3	4
SKCM	MYH11 →	-0.596	-1.353	.028	.014	3	4
LUSC	AMPK_pT172 →	-0.253	-2.106	.047	.018	3	3
STAD	FOXO3a_pS318_S321 →	-0.152	-3.169	.034	.017	3	3
STAD	Cyclin-E1 →	+0.401	+2.337	.040	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

ER-alpha_pS118 by PCDHA10 expression — LUAD

Explore this box plot interactively →