PCDH1

Across TCGA patient cohorts, PCDH1 mutation is significantly associated with the RNA expression of many other genes, with 2,660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCDH1-associated genes across cancer lineages are TOMM22, ABHD10, and MRPS33. Each is linked with PCDH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCDH1-to-partner and partner-to-PCDH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TOMM22 grouped by PCDH1-low versus PCDH1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH1→partner) and Y-score (partner→PCDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TOMM22 →	+0.496	+3.717	.001	<.001	3	3
STAD	ABHD10 →	+0.384	+3.235	.007	.008	3	3
STAD	MRPS33 →	+0.397	+3.346	.005	.004	3	3
SKCM	SCP2 →	+0.387	+3.360	.009	.004	3	3
SKCM	DNAJC8 →	+0.407	+2.019	.001	.001	3	3
SKCM	ZMYM6 →	+0.357	+2.166	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,660 associations by consensus.

TOMM22 by PCDH1 expression — STAD

Explore this box plot interactively →