PCDH1

Across TCGA pan-cancer cohorts, PCDH1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PCDH1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PCDH1 RNA is repressed in tumor relative to normal tissue. In most cancer types PCDH1 is over-expressed in tumor, although a few such as HNSC and KIRC show the opposite, repressed pattern.

HNSC, KIRC, and KIRP are the cancer types where PCDH1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCDH1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−1.504	<.001	11	view →
KIRC	Male	II,III,IV	−1.298	<.001	11	view →
KIRP	Female	All	−2.579	<.001	7	view →
THCA	All	All	+0.507	<.001	7	view →
LUSC	Female	II,III,IV	−2.205	<.001	6	view →
LIHC	All	III,IV	+0.765	.001	6	view →
BRCA	All	II,III,IV	+0.333	.002	6	view →
STAD	All	All	+0.985	<.001	4	view →
BLCA	All	IV	+1.797	.011	3	view →
COAD	All	All	−0.255	.034	3	view →
PAAD	All	All	+2.197	.047	2	view →
CHOL	All	All	+1.682	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PCDH1–HNSC

Open the HNSC breakdown →