PCDH1

Across TCGA cell cohorts, PCDH1 mutation is significantly associated with the RNA expression of many other genes, with 615 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCDH1-associated genes across cancer lineages are SEBOX, UHRF1BP1L, and TOX2. Each is linked with PCDH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCDH1-to-partner and partner-to-PCDH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEBOX grouped by PCDH1-low versus PCDH1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCDH1→partner) and Y-score (partner→PCDH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SEBOX →	+0.051	+3.044	<.001	.008	3	2
LARGE_INTESTINE	UHRF1BP1L →	+0.564	+3.364	.004	.002	3	2
LARGE_INTESTINE	TOX2 →	+1.334	+3.364	.001	.002	3	2
LARGE_INTESTINE	CCDC59 →	+0.487	+3.364	.002	.002	3	2
LARGE_INTESTINE	PPP4R2 →	+0.554	+3.364	.001	.002	3	2
LARGE_INTESTINE	CYB5D1 →	+1.045	+3.252	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 615 associations by consensus.

SEBOX by PCDH1 expression — STOMACH

Explore this box plot interactively →