PBX4

Across TCGA patient cohorts, PBX4 mutation is significantly associated with the RNA expression of many other genes, with 524 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PBX4-associated genes across cancer lineages are RNA5SP447, SNRPCP17, and LINC01815. Each is linked with PBX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PBX4-to-partner and partner-to-PBX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP447 grouped by PBX4-low versus PBX4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBX4→partner) and Y-score (partner→PBX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP447 →	+0.382	+5.201	.001	.007	3	2
STAD	SNRPCP17 →	+0.382	+3.804	<.001	.009	3	2
BLCA	LINC01815 →	+0.747	+5.329	<.001	.006	3	2
UCEC	IGHV3OR16-13 →	+0.564	+2.481	.005	.002	3	1
UCEC	IGKV1OR2-6 →	+0.782	+2.840	.004	<.001	3	1
UCEC	MAP3K4-AS1 →	+0.674	+3.330	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 524 associations by consensus.

RNA5SP447 by PBX4 expression — CESC

Explore this box plot interactively →