PBX4

Across TCGA pan-cancer cohorts, PBX4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PBX4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PBX4 RNA is repressed in tumor relative to normal tissue. In most cancer types PBX4 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where PBX4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PBX4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−3.142	<.001	11	view →
COAD	Female	All	+1.549	<.001	11	view →
KIRC	All	III,IV	+0.508	<.001	11	view →
HNSC	Male	III,IV	+0.866	<.001	9	view →
STAD	All	II,III,IV	+1.348	<.001	8	view →
KICH	Male	All	−1.230	<.001	6	view →
UCEC	All	All	+0.937	<.001	6	view →
CHOL	Male	All	+1.966	<.001	5	view →
READ	All	All	+1.657	<.001	5	view →
BLCA	Male	III,IV	+1.527	.007	4	view →
BRCA	All	IV	−0.600	.017	4	view →
ESCA	All	All	+1.292	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PBX4–THCA

Open the THCA breakdown →