PBRM1

Across TCGA patient cohorts, PBRM1 mutation is significantly associated with the RNA expression of many other genes, with 6,517 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PBRM1-associated genes across cancer lineages are MRTO4, RPL23AP82, and SF3B3. Each is linked with PBRM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PBRM1-to-partner and partner-to-PBRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRTO4 grouped by PBRM1-low versus PBRM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBRM1→partner) and Y-score (partner→PBRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRTO4 →	+0.321	+2.403	<.001	<.001	3	4
UCEC	RPL23AP82 →	+0.396	+2.080	<.001	<.001	3	4
UCEC	SF3B3 →	+0.435	+2.223	<.001	<.001	3	4
UCEC	KCTD9 →	+0.567	+1.635	<.001	<.001	3	4
UCEC	KCNK15 →	-1.139	-1.963	<.001	<.001	3	4
UCEC	L3MBTL2 →	+0.399	+1.799	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,517 associations by consensus.

MRTO4 by PBRM1 expression — UCEC

Explore this box plot interactively →