PBRM1

Across TCGA pan-cancer cohorts, PBRM1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PBRM1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PBRM1 RNA is repressed in tumor relative to normal tissue. In most cancer types PBRM1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where PBRM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PBRM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.568	<.001	8	view →
KIRC	All	II,III,IV	−0.430	<.001	6	view →
LIHC	All	All	+0.435	<.001	5	view →
CHOL	All	II,III,IV	+1.479	.003	4	view →
READ	Female	All	−0.839	.030	2	view →
ESCA	All	II,III,IV	−0.634	.044	2	view →
UCEC	All	All	−0.570	.019	2	view →
KICH	All	All	−0.546	.003	2	view →
LUSC	All	All	−0.220	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PBRM1–THCA

Open the THCA breakdown →