PBDC1

Across TCGA patient cohorts, PBDC1 mutation is significantly associated with the RNA expression of many other genes, with 2,209 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PBDC1-associated genes across cancer lineages are RN7SL248P, RNA5SP412, and MIR3135A. Each is linked with PBDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PBDC1-to-partner and partner-to-PBDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by PBDC1-low versus PBDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PBDC1→partner) and Y-score (partner→PBDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.054	+3.059	<.001	.005	3	3
UCEC	RNA5SP412 →	+0.737	+2.436	<.001	<.001	3	3
UCEC	MIR3135A →	+0.278	+2.038	.003	.006	3	3
UCEC	RNU4-58P →	+0.234	+2.718	<.001	<.001	3	3
LGG	RNU6-68P →	+0.298	+7.977	<.001	.007	3	2
UCEC	RNA5SP432 →	+0.762	+2.447	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,209 associations by consensus.

RN7SL248P by PBDC1 expression — UCEC

Explore this box plot interactively →