PAX7

Across TCGA cell cohorts, PAX7 mutation is significantly associated with the RNA expression of many other genes, with 861 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PAX7-associated genes across cancer lineages are FBXW10, OR5K1, and FAM205C. Each is linked with PAX7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAX7-to-partner and partner-to-PAX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FBXW10 grouped by PAX7-low versus PAX7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX7→partner) and Y-score (partner→PAX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FBXW10 →	+0.236	+2.714	<.001	.004	3	2
LUNG_SCLC	OR5K1 →	+0.043	+4.209	<.001	.006	3	1
SOFT_TISSUE	FAM205C →	+0.070	+4.930	<.001	.008	3	1
SOFT_TISSUE	PPIAL4F →	+0.056	+4.930	<.001	.008	3	1
CNS	VN1R4 →	+0.098	+5.754	<.001	.002	3	1
LUNG_NSCLC_LUAD	RETN →	+0.108	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 861 associations by consensus.

FBXW10 by PAX7 expression — LARGE_INTESTINE

Explore this box plot interactively →