PAX4

Across TCGA patient cohorts, PAX4 mutation is significantly associated with the RNA expression of many other genes, with 4,320 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAX4-associated genes across cancer lineages are SNORD116-11, MFRP, and MIR4774. Each is linked with PAX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PAX4-to-partner and partner-to-PAX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-11 grouped by PAX4-low versus PAX4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAX4→partner) and Y-score (partner→PAX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SNORD116-11 →	+0.130	+4.333	<.001	.004	3	3
LUSC	MFRP →	+0.021	+4.333	<.001	.004	3	3
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	3
LGG	SPANXN2 →	+0.035	+7.380	<.001	<.001	3	3
BLCA	ELOCP5 →	+0.135	+7.055	<.001	<.001	3	3
SARC	OR1D4 →	+0.088	+6.380	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,320 associations by consensus.

SNORD116-11 by PAX4 expression — LUSC

Explore this box plot interactively →