PAX4

Across TCGA pan-cancer cohorts, PAX4 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated PAX4 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PAX4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PAX4 expression acts as an unfavorable survival marker, although some lineages such as OV and LUSC show a favorable association.

LUAD, COAD, and DLBC are the cancer types where PAX4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.464	0.750	<.001	72	view →
COAD	OS	Quartile	IV	0.242	0.684	<.001	39	view →
DLBC	DFS	Tertile	III,IV	0.196	0.862	.008	36	view →
STAD	DFS	Quartile	III,IV	0.328	0.544	.003	34	view →
ESCA	OS	Tertile	All	0.108	1.000	<.001	33	view →
OV	OS	Tertile	III,IV	0.888	0.821	.017	30	view →
BLCA	DFS	Tertile	II,III,IV	0.377	0.521	.007	27	view →
THCA	DFS	Tertile	III,IV	0.760	0.944	.003	21	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	18	view →
CHOL	OS	Tertile	II,III,IV	0.024	0.601	.025	18	view →
LIHC	DFS	Tertile	III,IV	0.172	0.443	.026	9	view →
UCEC	DFS	Quartile	All	0.775	0.860	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

PAX4–LUAD (DFS)

Open the LUAD breakdown →